Yes, that’s the point. You don’t need it to run to fill a tire: just crank it over a few times with the starter then replace the spark plug and turn the fuel back on.

If you wanted to run the engine while once cylinder is connected to a tire then you’d very quickly overinflate it. Also you’d be running the engine without a cylinder (no spark plug) which is probably always a bad idea and in many cases straight up impossible.