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Naltrexone
I will start with naltrexone, which can help people who have difficulty regulating their drinking have a more natural and sustainable relationship with alcohol should they choose to not cut it out of their lives entirely.
It’s definitely effective, but you have to take a higher dose vs. IV. Usually it’s between 60 and 120mg and it’s delivered via troche in the cheek.
So that’s what ~1.5 mg/kg transdermal I guess. Assume some waste from swallowing. Yeah probably around the same delivery rate and dose as subcutaneous injection