Years ago I tried modding Fallout New Vegas and I think 4 on Fedora ages (I was running Fedora 28 at the time) ago using Mod Organizer 2 and it wouldn’t work for reasons I didn’t understand, possibly file system related. I’m thinking of switching to Pop! OS full time but I’d still like to play either modded Skyrim or FO4 from time to time, preferably using MO2.
I use vortex, it was dead simple to set up if you read the instructions (like disabling internet access and disabling update checking) and it has worked flawlessly for 1.5 years