Sorcery and Super Science might work for this. It’s already most of the way there. Most characters are mutants though and all humans are sorcerers so it might not be a perfect fit
You can also try a bit of a combo move with Worlds Without Number and Stars Without Number. Both games could probably handle this by themselves, but the rules are similar enough to combine which would give you scifi and magic together
You’re in trouble if their max is 1010 though