Yeah, I think at this point I do get the placebo effect first, pretty much immediately after taking the vitamin b-complex, as it works faster than I’d expect my body to really access those nutrients (though it is water soluable, so maybe it does start getting absorbed immediately), and I have had times where it feels like just the B is going to do the trick but then the tiredness returns a few mins later and I add the magnesium.

My approach to supplements in general is an assumption that I generally get most of what I need from my diet (which is better these days than it used to be earlier in my adult life), but that I’m probably not meeting all the needs consistently, so I’ll supplement it occasionally, either with a dose of multivitamin when I’m not feeling like anything is missing or with specific ones if I’m experiencing potential deficiency symptoms. I don’t want to supplement into overload, which can be as bad or worse than deficiency.

Also gotta watch out for the scam supplements, or ones suggested based on single properties without considering other consequences of them.

Eg, a little while ago, I bought some bromelain on a whim after seeing a claim it could dissolve eye floaters. Before taking one, I realized I had acted too quickly in buying them and did more reading and found out that even if it can get past the blood brain barrier and into the eyes (which is dubious at best), there’s nothing to stop it from dissolving other proteins inside the eyes, ones that aren’t just minor annoyances (speaking about my own situation, I understand floaters can get much worse than just annoying), and end up hurting your vision.