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Naltrexone
I will start with naltrexone, which can help people who have difficulty regulating their drinking have a more natural and sustainable relationship with alcohol should they choose to not cut it out of their lives entirely.
Ketamine
Fast acting relief from treatment resistant depression. Personally I find ~0.8 mg/kg subcutaneously injected is about the magic dose.
After 20 odd years of living in a fog the first time I used that treatment was like night and day. I had forgotten how trivial most things are without depression. Exercise for example is just “I don’t wanna but I know I’ll feel better. Ugh fine” instead of something that takes about 3 days to psych up to on a good week.
I find it’s very effective for about a week, dropping off over the next month or so. Unsure if lifetime sustainable at a frequency of ~2-3 weeks per dose but definitely useful to put in changes to life that make it easier to handle.
Crazy expensive medically though, if you can get it tested infusions can be prepared diy (most is diverted from medical supply so it’s often not adultrated BUT NOT ALWAYS!) with bacteriostatic water and 0.22 um wheel filters. Obvs if you don’t know what you’re doing you could seriously harm yourself, and you absolutely must be able to secure safety measures like naloxone, but if the rope is looking mighty appealing it’s an option if you can’t get it medically.
It’s worth noting that in the US there are ketamine therapy companies that send you oral ketamine in the mail. It costs about $120 per month and is accessible after a short zoom appointment.
I don’t know if it’s effective that way; all papers I’ve read that show affect are using nasal, IV, or subcutaneous.
That said you should probs try that before risking infection and gaol if it’s an option. It’s about that much a dose in Australia (has to be administered under supervision) and requires extensive screening.
It’s definitely effective, but you have to take a higher dose vs. IV. Usually it’s between 60 and 120mg and it’s delivered via troche in the cheek.
So that’s what ~1.5 mg/kg transdermal I guess. Assume some waste from swallowing. Yeah probably around the same delivery rate and dose as subcutaneous injection
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